Rulicent 5 | 7pcs | 14pcs | Discount Price
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Rulicent 5mg 7pcs Tablet

Generic: Ruxolitinib

Type: Tablet

Pack Size: 7pcs

Rulicent contains Ruxolitinib, a kinase inhibitor that blocks Janus Associated Kinases (JAK1 and JAK2). These enzymes mediate signaling pathways for cytokines and growth factors essential for blood cell production and immune function. Dysregulated JAK1 and JAK2 signaling is a hallmark of myelofibrosis (MF), a type of myeloproliferative neoplasm (MPN). By inhibiting these pathways, Ruxolitinib helps reduce spleen size, lowers the number of JAK2V617F mutant cells in the spleen, and decreases inflammatory cytokines such as TNF-α and IL-6.


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Discount Price: ৳ 1316
MRP: ৳ 1400 6% Off

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✅ Description:

Myelofibrosis: Rulicent is prescribed for adults with intermediate or high-risk myelofibrosis (MF), including primary MF, post-polycythemia vera MF, and post-essential thrombocythemia MF.

Polycythemia Vera: Rulicent is used to treat polycythemia vera (PV) in adults who have not responded adequately to or cannot tolerate hydroxyurea.

Acute Graft-Versus-Host Disease (GVHD): Rulicent is indicated for treating steroid-refractory acute GVHD in adults and children aged 12 years and older.
Use this medication only under the guidance of a registered physician.

  • Ruxolitinib is rapidly absorbed, with peak plasma concentrations occurring within 1–2 hours after oral administration. Its oral absorption rate is approximately 95%.
  • The steady-state volume of distribution in MF and PV patients is around 72 L.
  • The mean half-life of Ruxolitinib and its metabolites is about 5.8 hours, with an elimination half-life of approximately 3 hours.
  • Protein Binding 97%, mainly to albumin.
  • Primarily metabolized by CYP3A4 and to a lesser extent by CYP2C9.
  • Ruxolitinib is primarily eliminated through metabolism, with 74% excreted in urine and 22% in feces. Less than 1% of the total excreted radioactivity is an unchanged drug.

Safety Advices


Alcohol

It is not known if alcohol interacts with Rulicent 5. 


Pregnancy
UNSAFE

Rulicent 5 is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving Rulicent 5.


Breastfeeding
UNSAFE

Rulicent 5 is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving Rulicent 5. Your doctor may advise you to discontinue breastfeeding for a specific period or prescribe an alternative medicine based on your clinical condition.


Driving
CAUTION

If you experience dizziness after taking Rulicent 5 , avoid driving or operating heavy machinery.


Kidney
CONSULT YOUR DOCTOR

Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Rulicent 5.


Liver
CONSULT YOUR DOCTOR

Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Rulicent 5.

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✔️ Uses of Rulicent 5
  • Myelofibrosis
  • Polycythemia Vera
✔️ How does Rulicent 5 work?

Rulicent 5 works by blocking certain enzymes responsible for blood cell production.

✔️ Quick Suggestions:
  • Take Rulicent 5 exactly as prescribed by the doctor.
  • Do not take in larger or smaller quantities than recommended.
  • Take Rulicent 5 with or without food.
  • You may require frequent blood tests and a lipid profile while taking this medicine.
  • You may also require frequent follow-ups with your doctor to check the progress of treatment.
  • Do not stop the use of this medicine without consulting your doctor.
✔️ Indication of Rulicent 5

Ruxolitinib is an anticancer medication prescribed for the treatment of Polycythemia Vera, a type of blood cancer, and Myelofibrosis, a bone marrow disorder that impairs blood cell production. Its use is not recommended for individuals under 18 years of age.

✔️ Myelofibrosis (MF):

Myelofibrosis is a bone marrow disorder where scar tissue replaces healthy marrow, impairing its ability to produce normal blood cells. This leads to significant spleen enlargement. Common symptoms include abdominal fullness, bone pain, fatigue, easy bruising or bleeding, pale skin, and weight loss.

✔️ Polycythemia Vera (PV):

Polycythemia vera is a bone marrow condition characterized by the overproduction of red blood cells, causing the blood to thicken. Symptoms include headache, confusion, dizziness, itching, night sweats, and extreme fatigue.

✔️ Graft-versus-Host Disease (GVHD):

GVHD is a complication following transplantation where donor T cells attack the recipient's tissues, mistaking them as foreign. Symptoms may include abdominal pain, mouth ulcers, and skin rashes.

✔️ Dosage: Rulicent 5
  • Myelofibrosis (MF): Dosage depends on platelet count. Regular blood tests are required to monitor therapy.
    • Platelets >200 × 10⁹/L: 20 mg orally twice daily.
    • Platelets 100–200 × 10⁹/L: 15 mg orally twice daily.
    • Platelets 50–100 × 10⁹/L: 5 mg orally twice daily.
  • Polycythemia Vera (PV): The starting dose is 10 mg twice daily, adjusted based on safety and efficacy. For hemoglobin levels between 8–12 g/dL and platelets 50–75 × 10⁹/L, reduce the dose to 5 mg twice daily.
  • Acute GVHD: The initial dose is 5 mg twice daily, increasing to 10 mg twice daily after at least 3 days if blood counts are stable.
    Always follow a registered physician's directions.
  • Pediatric Use: Safety and efficacy in children have not been established.
✔️ Administration: Rulicent 5

Ruxolitinib is taken orally, with or without food. If a dose is missed, take the next scheduled dose without doubling up.
Use under the guidance of a registered physician.

✔️ Overdose:

No specific antidote is available. High doses may result in blood cell suppression (leukopenia, anemia, thrombocytopenia). Supportive care should be provided as needed.

✔️ Drug Interactions
  • Fluconazole: Doses above 200 mg/day may increase Ruxolitinib exposure, raising the risk of adverse effects. Avoid unless necessary for acute GVHD.
  • Strong CYP3A4 Inhibitors: Co-administration may increase Ruxolitinib levels. Consider dose reductions and monitor for toxicity, particularly with drugs like ketoconazole and itraconazole.
  • Strong CYP3A4 Inducers: May decrease Ruxolitinib levels. Monitor patients closely and adjust doses based on safety and efficacy.
✔️ Contraindications

Do not use in patients with a history of hypersensitivity to Ruxolitinib or any components of the medication.

✔️ Pregnancy and Lactation

There are no sufficient studies on the use of Ruxolitinib in pregnant women. It is unclear if the drug is excreted in breast milk. To minimize potential risks, breastfeeding should be avoided during treatment and for two weeks after the final dose.

✔️ Precautions & Warnings
  • Blood Cell Monitoring: Ruxolitinib can cause low blood cell counts (thrombocytopenia, anemia, neutropenia). Monitor complete blood counts (CBCs) regularly.
  • Infection Risk: Serious infections, including tuberculosis, have occurred. Delay treatment until active infections are resolved. Screen high-risk patients for latent tuberculosis.
  • Herpes Zoster and Hepatitis B: Monitor for symptoms and manage promptly if they arise.
  • Symptom Return After Stopping: Discontinuation may lead to a return of symptoms. Taper the dose gradually under a physician’s guidance.
  • Skin Cancer: Monitor periodically for non-melanoma skin cancers.
  • Lipid Levels: Ruxolitinib may increase cholesterol and triglycerides; monitor lipid levels 8–12 weeks after starting treatment.
✔️ Storage

Store below 30°C in a dry, dark place, away from children.

Frequently Asked Questions (FAQ)

Yes, Rulicent 5 mg Tablet may suppress the immune system, reducing your ability to fight infections and increasing the risk of serious infections. Consult your doctor if you experience symptoms like fever, chills, sweats, sore throat, cough, sores, or frequent/painful urination.

Avoid starting any new medications, including prescription drugs, over-the-counter medicines, herbal products, or supplements, without consulting your doctor during treatment with Rulicent 5 mg Tablet.

Yes, Rulicent 5 may increase the risk of tuberculosis, particularly in patients with latent TB (inactive infection). Inform your doctor if you have a history of TB or if you develop symptoms like a persistent cough, coughing up blood or mucus, weight loss, fever, night sweats, or fatigue.

The exact duration for which Jakavi 5 mg Tablet remains active in the body is not clinically established.

The peak effect of Jakavi 5 mg Tablet is typically observed within 1-2 hours after administration.
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Check our pricing section for Rulicent 5mg 7pcs Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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