Rulicent contains Ruxolitinib, a kinase inhibitor that blocks Janus Associated Kinases (JAK1 and JAK2). These enzymes mediate signaling pathways for cytokines and growth factors essential for blood cell production and immune function. Dysregulated JAK1 and JAK2 signaling is a hallmark of myelofibrosis (MF), a type of myeloproliferative neoplasm (MPN). By inhibiting these pathways, Ruxolitinib helps reduce spleen size, lowers the number of JAK2V617F mutant cells in the spleen, and decreases inflammatory cytokines such as TNF-α and IL-6.
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Myelofibrosis: Rulicent is prescribed for adults with intermediate or high-risk myelofibrosis (MF), including primary MF, post-polycythemia vera MF, and post-essential thrombocythemia MF.
Polycythemia Vera: Rulicent is used to treat polycythemia vera (PV) in adults who have not responded adequately to or cannot tolerate hydroxyurea.
Acute Graft-Versus-Host Disease (GVHD): Rulicent is indicated for treating steroid-refractory acute GVHD in adults and children aged 12 years and older.
Use this medication only under the guidance of a registered physician.
It is not known if alcohol interacts with Rulicent 5.
Rulicent 5 is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving Rulicent 5.
Rulicent 5 is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving Rulicent 5. Your doctor may advise you to discontinue breastfeeding for a specific period or prescribe an alternative medicine based on your clinical condition.
If you experience dizziness after taking Rulicent 5 , avoid driving or operating heavy machinery.
Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Rulicent 5.
Dose adjustment may be needed in patients with hepatic impairment. If you have a history of liver problems, inform the doctor before taking Rulicent 5.
Rulicent 5 works by blocking certain enzymes responsible for blood cell production.
Ruxolitinib is an anticancer medication prescribed for the treatment of Polycythemia Vera, a type of blood cancer, and Myelofibrosis, a bone marrow disorder that impairs blood cell production. Its use is not recommended for individuals under 18 years of age.
Myelofibrosis is a bone marrow disorder where scar tissue replaces healthy marrow, impairing its ability to produce normal blood cells. This leads to significant spleen enlargement. Common symptoms include abdominal fullness, bone pain, fatigue, easy bruising or bleeding, pale skin, and weight loss.
Polycythemia vera is a bone marrow condition characterized by the overproduction of red blood cells, causing the blood to thicken. Symptoms include headache, confusion, dizziness, itching, night sweats, and extreme fatigue.
GVHD is a complication following transplantation where donor T cells attack the recipient's tissues, mistaking them as foreign. Symptoms may include abdominal pain, mouth ulcers, and skin rashes.
Ruxolitinib is taken orally, with or without food. If a dose is missed, take the next scheduled dose without doubling up.
Use under the guidance of a registered physician.
No specific antidote is available. High doses may result in blood cell suppression (leukopenia, anemia, thrombocytopenia). Supportive care should be provided as needed.
Do not use in patients with a history of hypersensitivity to Ruxolitinib or any components of the medication.
There are no sufficient studies on the use of Ruxolitinib in pregnant women. It is unclear if the drug is excreted in breast milk. To minimize potential risks, breastfeeding should be avoided during treatment and for two weeks after the final dose.
Store below 30°C in a dry, dark place, away from children.
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